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pentobarbital will minimize the extent or effect of parecoxib by impacting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Keep an eye on.pentobarbital will lessen the extent or effect of dienogest/estradiol valerate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Gals should not decide on estradiol valerate/dienogest